TECHNOLOGIES
ENG
PRODUCTS

CHLOROHEXIDINE DIGLUCONATE (CHX)

ECORAD HARNESSES THE IMMENSE POWER OF CHLOROHEXIDINE DIGLUCONATE FAST-ACTING DISINFECTANT.

WHAT DOES CHX LOOK LIKE?
Chlorhexidine Gluconate, also known as CHX, is the gluconate salt form of Chlorhexidine.
CHX is known for its effectiveness against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses. Because of its topical antibacterial activity, CHX is also used as an antiseptic agent. It is used for skin disinfection before surgery and to sterilize surgical instruments.

WHY CHX?
Chlorhexidine Gluconate, also known as CHX is the gluconate salt form of Chlorhexidine. The name "chlorhexidine" breaks down as chlor(o) + hex(ane) + id(e) + (am)ine, and is a cationic poly biguanide.

WHERE IS IT USED?

PREVENTS GROWTH OF BIOFLIMS
While many antimicrobial agents have a difficult time entering biofilms and eliminating organisms within the biofilm, CHX has shown some ability to inhibit the adherence of microorganisms to a surface thereby preventing the growth and development of biofilms. Biofilms are a collective of one or more types of microorganisms that can grow on many different surfaces in a polymeric substance. They form a complex community of interactions and are contained within an extracellular matrix made of polymeric substance and proteins which protects the microbial cells and shields them, increasing their resistance to antimicrobials agents.

HOW DOES IT KILL/INHIBIT - BACTERIA
CHX has both bactericidal or bacteriostatic action against a wide range of gram-positive and gram-negative bacteria. The term “bactericidal” means it kills bacteria, while “bacteriostatic” refers to its ability to inhibit growth.

Even at low concentrations, CHX reacts with negatively charged bacterial cell surfaces, destroying the integrity of the cell membrane. Once the integrity of the membrane is destroyed, CHX rapidly penetrates into the cell and causes leakage of the intracellular components, leading to cell death. Gram-positive bacteria are even more sensitive to this agent. In higher concentrations, the CHX causes the cytoplasm to coagulate or solidify leading to cell death.

HOW DOES IT KILL/INHIBIT - FUNGI
​​The mechanism of action against fungi is very similar to bacteria. In a very short time, the fungus takes up CHX which impairs the integrity of the cell wall and the plasma membrane, and allowing CHX to enter the cytoplasm resulting in leakage of cell contents and cell death.

HOW DOES IT KILL/INHIBIT - VIRUSES
According to a report written by the CDC, unlike many other antimicrobials, CHX has demonstrated some effectiveness against microorganisms in different forms and states as well. This includes bacterial spores and protozoa. CHX has also been shown to have activity against enveloped viruses in vitro (e.g., herpes simplex virus, HIV, cytomegalovirus, influenza, and RSV).

What are the benefits of using CHX?
  • The advantage of CHX is that it has broad-spectrum efficacy, as well as very limited irritation potential on the skin. Using CHX in conjunction with Ethanol in a solution has the added advantage of decreasing the evaporation time of the ethanol while increasing the overall product efficacy once the ethanol has evaporated.

    CHX matches all the regulatory standards with ECHA authorization to sell for biocidal use under Article 95 and with REACH registration. It is also registered with the Cosmetic Ingredient Database which means that it can be used in cosmetics as a preservative with maximum concentration of 0.3%
  • According to many studies, scientists have discovered that, due to its positive charges, CHX binds strongly to skin, mucosa, and other tissues but is very poorly absorbed into our bloodstream. No detectable blood levels have been found following oral use. This means that this antimicrobial agent does not easily absorb into the skin, but instead, remains on the surface of the skin where it maintains an antimicrobial function.

    Historically, methods of interrupting pathogen transmission have focused on improving health care workers’ adherence to recommended infection control practices. A second complementary approach that was recommended was the decontamination of the patient's skin as well.
  • At EcoRad, we use a dual strategy for killing microorganisms. We pair the action of Ethanol with the persistent effects of CHX for a long-lasting effect. Our “Swipe N Wipes” are 5x thicker and are packaged in bulk to  to maximise and enable the disinfection of any surface.
    
    What if you could just ‘Swipe N Wipe’ once to disinfect and have a layer of protection that is only reserved for surgeons?


References

1.PubChem (n.d.). Chlorhexidine gluconate. [online] pubchem.ncbi.nlm.nih.gov. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/Chlorhexidine-gluconate.


2.Medicines.org.uk. (2015). Care Chlorhexidine Digluconate 0.2% w/v Antiseptic Mouthwash - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: https://www.medicines.org.uk/emc/product/4818/smpc.


3.M E B, G. (2019). Public Assessment Report Scientific discussion Chloorhexidinedigluconaat 0.5% m/v in Alcohol 70% v/v Denteck, cutaneous solution (chlorhexidine digluconate/ethanol). [online] Available at: https://www.geneesmiddeleninformatiebank.nl/pars/h120283.pdf [Accessed 19 Nov. 2021].


4.McDonnell, G. and Russell, A.D. (1999). Antiseptics and Disinfectants: Activity, Action, and Resistance. Clinical Microbiology Reviews, [online] 12(1), pp.147–179. Available at: https://cmr.asm.org/content/12/1/147.


5. Puig Silla, Miriam et al. “Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature.” Medicina oral, patologia oral y cirugia bucal vol. 13,4 E257-60. 1 Apr. 2008


6.Orsi, G B, and V Ciorba. “Vancomycin resistant enterococci healthcare associated infections.” Annali di igiene : medicina preventiva e di comunita vol. 25,6 (2013): 485-92. doi:10.7416/ai.2013.1948


7.Vernon MO, Hayden MK, Trick WE, et al. Chlorhexidine Gluconate to Cleanse Patients in a Medical Intensive Care Unit: The Effectiveness of Source Control to Reduce the Bioburden of Vancomycin-Resistant Enterococci. Arch Intern Med. 2006;166(3):306–312. doi:10.1001/archinte.166.3.306


8.Chlorhexidinefacts.com. (2012). Chlorhexidine Facts: Mechanism of Action. [online] Available at: https://www.chlorhexidinefacts.com/mechanism-of-action.html.


9.Mohammadi, Z. and Abbott, P.V. (2009). The properties and applications of chlorhexidine in endodontics. International Endodontic Journal, 42(4), pp.288–302.


10.Aparna Vidyasagar (2016). What Are Biofilms? [online] Live Science. Available at: https://www.livescience.com/57295-biofilms.html.


11.Centers for Disease Control and Prevention. Guideline for Hand Hygiene in Health-Care Settings: Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR 2002;51(No. RR16):[1-48].


12.RN Laboratories AG. (n.d.). Chlorhexidine Gluconate 20% – Regulatory Status. [online] Available at: https://chlorhexidine.ch/content/chlorhexidine-gluconate-20-regulatory-status/.

TECHNOLOGIES
LEARN MORE ABOUT BAC
LEARN MORE ABOUT ETHANOL
WANT TO JOIN OUR TEAM?
Would you like to be our Distributor?
If you would like to import and resell our products in your country

Would you like to be our Sales Representative?
Would you like to find clients and earn commission from every sale they will make